Vice President JD Vance during a meeting with Taoiseach Micheál Martin ahead of the White House St. Patrick's Day reception in Washington in March. (Niall Carson/PA Images via Getty Images)
There are 53 Republicans in the Senate, meaning three Republican senators could opt out of voting for the bill, and it could still pass with Vance's support.
Vance has previously cast tie-breaking votes in the Senate, including in January to confirm Trump’s pick for Secretary of Defense, Pete Hegseth, and on a measure in April to curb Trump’s ability to impose global tariffs.
Vance’s office declined to provide comment to Fox News Digital.
Republican lawmakers who’ve historically voiced concerns about certain Medicaid provisions included in the "big, beautiful, bill" include senators Susan Collins of Maine, Josh Hawley of Missouri and Lisa Murkowski of Alaska. These lawmakers have cautioned that the reforms would prove detrimental to rural hospitals in their states.
Spokespeople for Collins, Hawley and Murkowski did not immediately respond to a request for comment from Fox News Digital.
Sen. Susan Collins, R-Maine, with supporters outside the Kittery Trading Post, where she was greeted by KTP Vice President Fox Keim. (Rich Beauchesne/Seacoastonline)
Earlier this month, Vance met with Republican senators to discuss the measure during a closed-door lunch and said afterward he was hopeful about the odds of passing the legislation on time.
"I mean, look, I can’t make any promises. … I can’t predict the future, but I do think that we’re in a good place to get this done by the July 4 recess," Vance told reporters June 17.
Vance also told reporters that despite concerns from lawmakers, including Collins, regarding certain Medicaid provisions included in the measure, he would work to address any issues raised. Still, he said there was broad agreement within the party on reforming Medicaid to block access for illegal immigrants.
"They’re all very confident we’re eventually going to get there," Vance said.
CLICK HERE TO GET THE FOX NEWS APP
President Donald Trump holds a photo of Katie Abraham as her father, Joe Abraham, left, watches during an event to promote Trump's domestic policy and budget agenda in the East Room of the White House. (AP Photo/Mark Schiefelbein)
The House narrowly passed its version of the measure in May by a 215-214 margin, with two Republicans voting against the legislation.
Trump urged lawmakers to get the legislation to the finish line Thursday, labeling the measure the "single-most important piece of border legislation ever to cross the floor of Congress."
"This is the ultimate codification of our agenda to — very simply, a phrase that's been used pretty well by me over the past 10 years, but maybe even before that — make America great again," Trump said at a "One, Big, Beautiful Event" at the White House Thursday.
Diana Stancy is a politics reporter with Fox News Digital covering the White House.
https://www.foxnews.com/politics/jd-vance-poised-clinch-victory-trumps-landmark-bill-gop-finalizes-strategy